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Chemical Structure : DC-B01
Catalog No.: PC-49189Not For Human Use, Lab Use Only.
DC-B01 is a novel small molecule BCL-2 inhibitor that binds to the BH4 domain with KD of 2.16 uM, disrupts the BCL-2/c-Myc interaction and consequently suppresses the transcriptional activity of c-Myc.
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DC-B01 is a novel small molecule BCL-2 inhibitor that binds to the BH4 domain with KD of 2.16 uM, disrupts the BCL-2/c-Myc interaction and consequently suppresses the transcriptional activity of c-Myc.
DC-B01 inhibitor cell growth of RS;4:11, H460 and A375 cells with IC50 of 3.15, 3.74 and 14.47 uM, respectively.
DC-B01 induced cell killing in a BCL-2-dependent manner and triggered apoptosis via the mitochondria-mediated pathway.
DC-B01 (15 mg/kg/day) inhibited tumor growth in vivo in a BCL‑2‑dependent manner.
| M.Wt | 549.38 | |
| Formula | C22H20IN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jing-Yi Zhou, et al. Acta Pharmacol Sin. 2022 Aug 2. doi: 10.1038/s41401-022-00936-0.
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