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DC-Rhoin

Chemical Structure : DC-Rhoin

CAS No.: 343348-12-9

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DC-Rhoin (DC-RC-063)

Catalog No.: PC-28589Not For Human Use, Lab Use Only.

DC‐Rhoin (DC-RC-063) is a selective, covalent small molecule inhibitor of Rho family GTPase RhoA protein, inhibits GDP/GTP exchange rate of RhoA with IC50 of 2.94 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DC‐Rhoin (DC-RC-063) is a selective, covalent small molecule inhibitor of Rho family GTPase RhoA protein, inhibits GDP/GTP exchange rate of RhoA with IC50 of 2.94 uM.
DC‐Rhoin captures a novel allosteric pocket around cysteine 107 (Cys107), blocks the interaction RhoA with RhoGEF and RhoGDI.
DC‐Rhoin selectively inhibits the interactions between Rho family proteins (RhoA, Cdc42, and Rac1) and their respective GEFs.
Among the Ras superfamily of GTPases, the Cys107 residue is unique and relatively conserved within the Rho family.

Physicochemical Properties

M.Wt 250.27
Formula C12H10O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

allyl benzo[b]thiophene-3-carboxylate 1,1-dioxide

References

1. Zhongya Sun, et al. Adv Sci (Weinh). 2020 May 13;7(14):2000098.

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