DC260126 is a potent GPR40 (FFAR1) agonist with IC50 of 6.28 uM for inhibition of Ca2+ stimulated by linoleic acid.
DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells.
DC260126 improves insulin tolerance but not glucose tolerance in obese Zucker rats.
Physicochemical Properties
M.Wt
307.383
Formula
C16H18FNO2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-butylphenyl)-4-fluorobenzenesulfonamide
References
1. Sun P, et al. PLoS One. 2013 Jun 11;8(6):e66744.
2. Zhang X, et al. Biomed Pharmacother. 2010 Nov;64(9):647-51.
3. Hu H, et al. Biochem Biophys Res Commun. 2009 Dec 18;390(3):557-63.
