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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-DCCCyB
DCCCyB

Chemical Structure : DCCCyB

CAS No.: 1236046-15-3

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DCCCyB (GlyT1 inhibitor)

Catalog No.: PC-61457Not For Human Use, Lab Use Only.

DCCCyB is a potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DCCCyB is a potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo.

    Physicochemical Properties

    M.Wt 458.438
    Formula C22H29Cl2NO3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,4-dichloro-N-(((1s,4s)-1-(cyclopropylmethyl)-4-((cyclopropylmethyl)sulfonyl)cyclohexyl)methyl)benzamide

    References

    1. Blackaby WP, et al. ACS Med Chem Lett. 2010 Jun 25;1(7):350-4.

    2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640.

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