Chemical Structure : DCY1040
CAS No.:
Catalog No.: PC-25469Not For Human Use, Lab Use Only.
DCY1040 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.0 uM and 105.9-fold potentiation, directly binds to TMEM175.
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DCY1040 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.0 uM and 105.9-fold potentiation, directly binds to TMEM175.
DCY1040 and TUG-891 synergistically activate TMEM175
DCY1040 activates TMEM175 more effectively than DCPIB (Cat# PC-72941).
DCY1040 restores PD-related variants in TMEM175.
DCY1040 promotes the removal of aberrant α-synuclein both in vitro and in vivo.
| M.Wt | 432.52 | |
| Formula | C23H30F2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(3-(1H-tetrazol-5-yl)propoxy)-2-butyl-2-cyclohexyl-6,7-difluoro-2,3-dihydro-1H-inden-1-one |
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1. Xuewu Zhu, et al. Structural insights into the activation of TMEM175 by small molecule. Neuron. 2025 Aug 22:S0896-6273(25)00556-2.

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