Chemical Structure : DCZ0415
CAS No.: 2242470-43-3
Catalog No.: PC-38128Not For Human Use, Lab Use Only.
DCZ0415 (DCZ-0415) is a small-molecule inhibitor targeting TRIP13 with Kd of 2.42 uM in SPR assay.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $178 | In stock | |
25 mg | $288 | In stock | |
50 mg | $458 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DCZ0415 (DCZ-0415) is a small-molecule inhibitor targeting TRIP13 with Kd of 2.42 uM in SPR assay.
DCZ0415 inhibits the proliferation of multiple myeloma cell lines and induces apoptosis.
Using CCK-8 assay, the IC50 value of DCZ0415 was 1.0-10 μmol/L calculated by CalcuSyn in multiple myeloma cell lines.
DCZ0415 impaired DNA repair and inhibited NF-κB activity in multiple myeloma cells.
DCZ0415 in combination with melphalan or panobinostat functions synergistically to exert cytotoxicity. DCZ0415 demonstrates antitumorigenic effects in a xenograft model of multiple myeloma.
M.Wt | 356.425 | |
Formula | C23H20N2O2 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione |
1. Yingcong Wang, et al. Cancer Res. 2020 Feb 1;80(3):536-548.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright