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Chemical Structure : DCZ19931
Catalog No.: PC-49582Not For Human Use, Lab Use Only.
DCZ19931 is a novel multi-targeting kinase inhibitor, exhibits anti-angiogenic effects in vitro and inhibits ocular neovascularization in vivo.
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DCZ19931 is a novel multi-targeting kinase inhibitor, exhibits anti-angiogenic effects in vitro and inhibits ocular neovascularization in vivo.
DCZ19931 (1 nM-10 uM) has no obvious cytotoxicity and tissue toxicity.
DCZ19931 (2 μL, 1 μg/μL) inhibits ocular neovascularization in C57BL/6J mice.
DCZ19931 exhibited anti-angiogenic effects in vitro, DCZ19931 plus Ranibizumab showed greater anti-angiogenic effects than DCZ19931 or Ranibizumab monotherapy.
DCZ19931 inhibited vascular permeability via downregulation of ICAM-1 expression.
DCZ19931 inhibited ocular neovascularization through p38-MAPK and ERK1/2-MAPK signaling.
| M.Wt | 549.45 | |
| Formula | C26H20F5N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang H, et al. Sci Rep. 2022 Dec 13;12(1):21539.
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