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Chemical Structure : DD-03-171
Catalog No.: PC-35884Not For Human Use, Lab Use Only.
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.
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DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.
DD-03-171 also displays efficacy against patient-derived xenografts in vivo.
| M.Wt | 991.163 | |
| Formula | C55H62N10O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dobrovolsky D, et al. Blood. 2018 Dec 13. pii: blood-2018-07-862953. doi: 10.1182/blood-2018-07-862953.
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