DDC-03-024-01

Chemical Structure : DDC-03-024-01

Catalog No.: PC-73295Not For Human Use, Lab Use Only.

DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM.

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Biological Activity

DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM.
DDC-03-024-01 displays no significant activity aginst WT EGFR (IC50>1000 nM) and high selectivity by kinome profiling.
Cotreatment with cetuximab resulted in antiproliferative activity in EGFR mutant Ba/F3 cells (IC50=0.36 uM, L858R/T790M).

Physicochemical Properties

M.Wt	508.597
Formula	C31H29FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Dries J H De Clercq, et al. ACS Med Chem Lett. 2019 Oct 22;10(11):1549-1553.

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DDC-03-024-01

Biological Activity

Physicochemical Properties

References

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