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DDC4002

Chemical Structure : DDC4002

CAS No.: 2375048-04-5

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DDC4002 (DDC 4002, DDC-4002 )

Catalog No.: PC-21851Not For Human Use, Lab Use Only.

DDC4002 is a potent, selective and allosteric EGFR inhibitor, shows selectivity against L858R/T790M/C797S EGFR mutants with IC50 of 39-50 nM, does not inhibit WT EGFR.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDC4002 is a potent, selective and allosteric EGFR inhibitor, shows selectivity against L858R/T790M/C797S EGFR mutants with IC50 of 39-50 nM, does not inhibit WT EGFR.

Physicochemical Properties

M.Wt 318.35
Formula C20H15FN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

References

1. Maity S, et al. Pharmacol Rep. 2020 Aug;72(4):799-813.

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