DDD00079282

Chemical Structure : DDD00079282

Catalog No.: PC-28183Not For Human Use, Lab Use Only.

DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM.

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Biological Activity

DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM.

Physicochemical Properties

M.Wt	291.33
Formula	C12H13N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide

References

1. Yumi Park, et al. ACS Infect Dis. 2017 Jan 13;3(1):18-33.

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DDD00079282

Biological Activity

Physicochemical Properties

References

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