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DDI-4

Chemical Structure : DDI-4

CAS No.: 1212218-68-2

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DDI-4

Catalog No.: PC-27898Not For Human Use, Lab Use Only.

DDI-4 is a dual activator of nematode membranous organelle fusion (MOF) and mouse acrosome reaction (ASR), triggers exocytotic sperm remodeling not only in worms but also in mice.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDI-4 is a dual activator of nematode membranous organelle fusion (MOF) and mouse acrosome reaction (ASR), triggers exocytotic sperm remodeling not only in worms but also in mice.
DDI-4 activates the ASR and induces IZUMO1 relocation in mouse spermatozoa
DDI-4 activates an exocytotic sperm remodeling pathway distinguishable from canonical Pron- and ProK-mediated pathways
DDI-4 is predicted to target sphingosine kinases (SPHKs)
DDI-4–induced MOF requires the tRNA methyltransferase NSUN-2 and the sphingosine kinase SPHK-1.

Physicochemical Properties

M.Wt 191.32
Formula C13H21N
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-(4-pentylphenyl)ethan-1-amine

References

1. Yoshihiro Shimada, et al. PLoS Genet. 2026 Aug 27;22(8):e1012275.

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