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Chemical Structure : DDR-TRK-1
Catalog No.: PC-35847Not For Human Use, Lab Use Only.
DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM.
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DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM.
DDR-TRK-1 inhibits colony formation and migration of Panc-1 pancreatic cancer cells.
In cellular and mouse models of lung fibrosis, DDR-TRK-1 inhibits signaling, expression of fibrotic markers and fibrotic features such as hydroxproline expression.
DDR-TRK-1 is selective in KINOMEscan at 1 uM,t he closest off target is CDK11 (370 nM).
| M.Wt | 492.506 | |
| Formula | C26H23F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Z, et al. J Med Chem. 2016 Jun 23;59(12):5911-6.
2. PCT Int. Appl. (2016), WO 2016064970 A1 20160428.
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