Chemical Structure : DDR1-IN-2
CAS No.:
1315329-35-1
DDR1-IN-2
Catalog No.: PC-24448Not For Human Use, Lab Use Only.
DDR1-IN-2 is a potent and selective inhibitor of DDR1 receptor tyrosine kinase with IC50 of 47.6 nM, 4-fold selective over DDR-2 (IC50=145 nM), inhibits DDR1 autophosphorylation in cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDR1-IN-2 is a potent and selective inhibitor of DDR1 receptor tyrosine kinase with IC50 of 47.6 nM, 4-fold selective over DDR-2 (IC50=145 nM), inhibits DDR1 autophosphorylation in cells.
DDR1-IN-2 exhibits excellent selectivity for DDR1 with selectivity score (S(1) at 1 μM) of 0.07 as assessed using the KinomeScan approach.
DDR1-IN-2 blocks collagen induced DDR1 autophosphorylation in U2OS cells with EC50 of 9.45 nM.
DDR1-IN-2 exhibits anti-proliferation effect against a panel of different cancer cell lines (HCT-116(OWT), IC50=0.81 uM).
Physicochemical Properties
|
M.Wt
|
580.66
|
|
Formula
|
C31H35F3N6O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-((4-ethylpiperazin-1-yl)methyl)-N-(3-(((4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide
|
References
1. Kim HG, et al.ACS Chem Biol. 2013 Oct 18;8(10):2145-50.
Contact Us
sales@probechem.com
