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DEL-C1

Chemical Structure : DEL-C1

CAS No.:

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DEL-C1

Catalog No.: PC-25794Not For Human Use, Lab Use Only.

DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

    Physicochemical Properties

    M.Wt 695.88
    Formula C38H45N7O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R)-N-((S)-1-(1H-indol-3-yl)-4-(((R)-3-(methylamino)-3-oxo-1-phenylpropyl)amino)-4-oxobutan-2-yl)-2-(((2-(2,4-dimethylthiazol-5-yl)oxazol-5-yl)methyl)amino)cyclohexane-1-carboxamide

    References

    1. Kaur B, et al. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.

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