Catalog No.: PC-47007Not For Human Use, Lab Use Only.
DF-006 is a small molecule, orally active Alpha-kinase 1 (ALPK1) agonist, activates ALPK1 and stimulates host innate immunity locally in liver, DF-006 enacts potent anti-HBV responses in mouse models of HBV and in primary human hepatocytes.
DF-006 is a small molecule, orally active Alpha-kinase 1 (ALPK1) agonist, activates ALPK1 and stimulates host innate immunity locally in liver, DF-006 enacts potent anti-HBV responses in mouse models of HBV and in primary human hepatocytes.
DF-006 rapidly reduced serum HBV DNA, HBsAg and HBeAg levels using doses as low as 0.08, 1 and 5 μg/kg, respectively, in mouse models.
DF-006 in combination with the HBV nucleoside reverse transcriptase inhibitor, entecavir further reduced HBV DNA.
DF-006 also showed anti-HBV efficacy in PHH, with significant reductions of HBV DNA, at sub-nanomolar concentrations.
DF-006 up-regulateed NF-κB-targeted genes that are involved in innate immunity.
