Chemical Structure : DFL23916
CAS No.:
2185867-25-6
DFL23916
Catalog No.: PC-24589Not For Human Use, Lab Use Only.
DFL23916 is a new selective, dual GPR40 and GPR120 agonist with AC50 of 16.6 µM on human GPR120 short isoform and AC50 of 13.7 µM on human GPR40.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DFL23916 is a new selective, dual GPR40 and GPR120 agonist with AC50 of 16.6 µM on human GPR120 short isoform and AC50 of 13.7 µM on human GPR40.
DFL23916 has AC50 of 10.2 ± 0.5 µM and 11.5 ± 0.8 µM towards huamn GPR120 and GPR40, respectively, in β-arrestin assays.
DFL23916 shows no activity towards several receptors as hGLP1R, hGPR43, hGPR119, hTGR5, with an AC50 > 1 mM.
DFL23916 is a dual agonist of mouse GPR120 and GPR40.
DFL23916 stimulates GLP-1 secretion in human NCI-H716 and in mouse STC-1 enteroendocrine cell lines.
DFL23916 (100 mg/kg, p.o.) significantly reduced the glycemia excursion after glucose in vivo.challenge
Physicochemical Properties
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M.Wt
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469.57
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Formula
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C26H28FNO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-(3-(N-(6-fluoro-4-methyl-[1,1'-biphenyl]-3-yl)sulfamoyl)phenyl)heptanoic acid
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References
1. Bianchini G, et al. Biomed Pharmacother. 2021 Jul;139:111613.
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