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Chemical Structure : DFP-10917 hydrochloride
CAS No.: 135598-68-4
Catalog No.: PC-35236Not For Human Use, Lab Use Only.
DFP-10917 hydrochloride (CNDAC, TAS-109) is a deoxycytidine analog with antitumor activity against various tumor cells, is an orally available nucleoside analog prodrug of CNDAC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DFP-10917 hydrochloride (CNDAC, TAS-109) is a deoxycytidine analog with antitumor activity against various tumor cells, is an orally available nucleoside analog prodrug of CNDAC.
CNDAC is phosphorylated to generate its nucleotide form, functioning as a deoxycytosine mimic and is incorporated into DNA in tumor cells, causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, resulting in G2/M phase-arrest and tumor cell apoptosis.
| M.Wt | 288.69 | |
| Formula | C10H13ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile hydrochloride |
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1. Matsuda A, et al. J Med Chem. 1991 Sep;34(9):2917-9.
2. Sankhala K, et al. Invest New Drugs. 2018 Apr 18. doi: 10.1007/s10637-018-0602-0.
3. Hanaoka K, et al. Int J Cancer. 1999 Jul 19;82(2):226-36.
4. Tanaka M, et al. Cancer Lett. 1992 May 30;64(1):67-74.
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