DG-041 (DG041) is a potent and selective prostanoid EP3 receptor antagonist with IC50 of 4.6 nM and 8.1 nM in binding and FLIPR assay, respectively.
DG-041 antagonized the effects of sulprostone on platelet function.
DG-041 potentiated the protective effects of PGE(2) on platelet aggregation by inhibiting the pro-aggregatory effect via EP3 stimulation.
DG041 (30 mg/kg) enhanced bladder capacity, inhibited the responses to GR63799X supporting the in vivo activity.
