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Chemical Structure : DG051
CAS No.: 929915-58-2
Catalog No.: PC-42712Not For Human Use, Lab Use Only.
DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis.
DG051 dispalys selectivity over a panel of more than 50 targets including aminopeptidases, hERG, GPCRs.
DG051 has high aqueous solubility (>30 mg/mL) and high oral bioavailability.
| M.Wt | 426.3335 | |
| Formula | C21H25Cl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 325 mg/mL |
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| Chemical Name/SMILES |
1-Pyrrolidinebutanoic acid, 2-[[4-(4-chlorophenoxy)phenoxy]methyl]-, hydrochloride (1:1), (2S)- |
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1. Sandanayaka V, et al. J Med Chem. 2010 Jan 28;53(2):573-85.
2. Enache LA, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6275-9.
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