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Chemical Structure : DGY-06-116
CAS No.: 2556836-50-9
Catalog No.: PC-72224Not For Human Use, Lab Use Only.
DGY-06-116 (SRC inhibitor 15a) is a potent, selective, covalent Src inhibitor (biochemical IC50=3 nM) that taregrs a P-Loop cysteine (Cys277).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $558 | In stock | |
| 250 mg | Get quote |
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DGY-06-116 (SRC inhibitor 15a) is a potent, selective, covalent Src inhibitor (biochemical IC50=3 nM) that taregrs a P-Loop cysteine (Cys277).
BTK, ABL, and most SFK family members such as HCK, BLK, LCK, and YES1 were the main off-targets as confirmed with low nanomolar biochemical IC50s.
DGY-06-116 demonstrated potent antiproliferative effects in lung and breast cancer cell lines (H1957 GI50=0.3 uM).
DGY-06-116 inhibited p-SRCY416 signaling in both H1975 and HCC827 cells at 1 uM.
DGY-06-116 inhibited p-SRCY416 at 2 and 4 h postdosing in spleen tissue samples from C57B6 mice.
| M.Wt | 597.12 | |
| Formula | C32H33ClN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((2-Acrylamidophenyl)amino)-N-(2-chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide |
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1. Guangyan Du, et al. J Med Chem. 2020 Feb 27;63(4):1624-1641.
2. Gurbani D, et al. Front Mol Biosci. 2020 May 19;7:81.
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