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DH-376

Chemical Structure : DH-376

CAS No.: 1848233-57-7

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DH-376 (DH376)

Catalog No.: PC-61836Not For Human Use, Lab Use Only.

DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively.
    DH-376 shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 (pIC50=7.0) and PLA2G7.
    DH-376 significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.

    Physicochemical Properties

    M.Wt 542.587
    Formula C31H28F2N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((2R,5R)-2-benzyl-5-(prop-2-yn-1-yloxy)piperidin-1-yl)(4-(bis(4-fluorophenyl)(hydroxy)methyl)-2H-1,2,3-triazol-2-yl)methanone

    References

    1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.

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