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Chemical Structure : DH-376
Catalog No.: PC-61836Not For Human Use, Lab Use Only.
DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively.
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DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively.
DH-376 shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 (pIC50=7.0) and PLA2G7.
DH-376 significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.
| M.Wt | 542.587 | |
| Formula | C31H28F2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.
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