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DI-87

Chemical Structure : DI-87

CAS No.: 2107280-55-5

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DI-87 ((R)-DI-87, TRE-515)

Catalog No.: PC-38835Not For Human Use, Lab Use Only.

DI-87 ((R)-DI-87, TRE-515) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DI-87 ((R)-DI-87, TRE-515) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.
(R)-DI-87 treatment rescued CEM cells from the anti-proliferative effects of gemcitabine, a dCK-dependent nucleoside analog prodrug, with an EC50 of 10.2 nM.
(R)-DI-87 is a promising new compound for use in combination therapy against tumors expressing dCK.

Physicochemical Properties

M.Wt 502.652
Formula C23H30N6O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[(1R)-1-[2-[4-Methoxy-3-[2-(4-morpholinyl)ethoxy]phenyl]-5-methyl-4-thiazolyl]ethyl]thio]-4,6-pyrimidinediamine

References

1. Soumya Poddar, et al. Biochem Pharmacol. 2020 Feb;172:113742.

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