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Chemical Structure : DI-87
Catalog No.: PC-38835Not For Human Use, Lab Use Only.
DI-87 ((R)-DI-87) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.
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DI-87 ((R)-DI-87) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.
(R)-DI-87 treatment rescued CEM cells from the anti-proliferative effects of gemcitabine, a dCK-dependent nucleoside analog prodrug, with an EC50 of 10.2 nM.
(R)-DI-87 is a promising new compound for use in combination therapy against tumors expressing dCK.
| M.Wt | 502.652 | |
| Formula | C23H30N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soumya Poddar, et al. Biochem Pharmacol. 2020 Feb;172:113742.
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