DIDS |CAS:304655-84-3 Probechem Biochemicals

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Chemical Structure : DIDS

DIDS

Catalog No.: PC-61230Not For Human Use, Lab Use Only.

DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.
DIDS inhibits repair of activation-induced cytidine deaminase (AID)-initiated DNA breaks, induces apoptosis, and promotes cytotoxicity preferentially in AID-expressing human CLL;.
DIDS strongly inhibits T1D development in NOD mice.

Physicochemical Properties

M.Wt	516.483
Formula	C16H10N2Na2O7S4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-diisothiocyanatostilbene-2, 2'-disulfonic acid disodium hydrate

References

1. Ratiu JJ, et al. J Immunol. 2017 Jun 1;198(11):4255-4267.

2. Lamont KR, et al. Exp Med. 2013 May 6;210(5):1021-33.

3. Dinnen RD, et al. Mol Cancer Ther. 2013 Dec;12(12):2792-803.

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DIDS

Biological Activity

Physicochemical Properties

References

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