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Chemical Structure : DJ101
Catalog No.: PC-60807Not For Human Use, Lab Use Only.
A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.
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DJ101 is a potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.
DJ101 demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM.
DJ101 disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration.
DJ101 inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model.
| M.Wt | 400.438 | |
| Formula | C23H20N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277.
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