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DJ4

Chemical Structure : DJ4

CAS No.:

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DJ4 (ROCK inhibitor DJ4)

Catalog No.: PC-35150Not For Human Use, Lab Use Only.

DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively.
    DJ4 minimally inhibits PAK1 and DMPK, inhibits the phosphorylation of recombinant MYPT1(Thr696) by recombinant ROCK1 and ROCK2.
    DJ4 significantly blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell lines in a concentration dependent manner, which is independent of cell death.

    Physicochemical Properties

    M.Wt 350.44
    Formula C19H18N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2Z,5E)-5-((3a,7a-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-(phenethylimino)thiazolidin-4-one

    References

    1. Kale VP, et al. Cancer Lett. 2014 Nov 28;354(2):299-310.

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