DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays.
DK419 reduces levels of Wnt/β-catenin target gene proteins (Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin) in CRC tumor cell models, increases oxygen consumption rate and induces pAMPK in cell culture.
DK419 potently inhibit the proliferation of CRC tumor cell lines (SW948 cell IC50=0.07 uM).
DK419 displays inhibition of tumor growth in mouse CRC240 PDX tumor model.
