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DKR-1051

Chemical Structure : DKR-1051

CAS No.: 2089053-14-3

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DKR-1051 (DKR 1051;DKR1051)

Catalog No.: PC-61102Not For Human Use, Lab Use Only.

DKR-1051 is a novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DKR-1051 is a novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM).
    DKR-1051 modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells。
    DKR-1051 relieves spared nerve injury-induced mechanical hypersensitivity in vivo.

    Physicochemical Properties

    M.Wt 385.474
    Formula C24H26F3N
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,6R)-2-cyclopentyl-9-(4-(trifluoromethyl)phenyl)-1,2,3,4,5,6-hexahydro-1,6-methanobenzo[c]azocine

    References

    1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575.

    2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.

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