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Chemical Structure : DL5050
Catalog No.: PC-49716Not For Human Use, Lab Use Only.
DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8).
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DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8).
DL5050 preferentially induced the expression of CYP2B6 (target of hCAR) over CYP3A4 (target of hPXR) on both the mRNA and protein levels in cultured human primary hepatocytes (HPH).
DL5050 displayed a strong induction preference in CYP2B6 over CYP3A4, which exceeds that of the known hCAR activator CITCO (Cat# PC-49715).
DL5050 is a tool for elucidating biological functions of hCAR with minimal hPXR interference.
| M.Wt | 420.67 | |
| Formula | C19H12Cl3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang D, et al. ACS Med Chem Lett. 2019 Jun 12;10(7):1039-1044.
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