Catalog No.: PC-49716Not For Human Use, Lab Use Only.
DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8).
DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8).
DL5050 preferentially induced the expression of CYP2B6 (target of hCAR) over CYP3A4 (target of hPXR) on both the mRNA and protein levels in cultured human primary hepatocytes (HPH).
DL5050 displayed a strong induction preference in CYP2B6 over CYP3A4, which exceeds that of the known hCAR activator CITCO (Cat# PC-49715).
DL5050 is a tool for elucidating biological functions of hCAR with minimal hPXR interference.
