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DLK-LZK inhibitor 64

Chemical Structure : DLK-LZK inhibitor 64

CAS No.: 2229958-91-0

DLK-LZK inhibitor 64

Catalog No.: PC-49571Not For Human Use, Lab Use Only.

DLK-LZK inhibitor 64 (example 64) is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK) inhibitor with IC50 of 2 nM and 10 nM, respectively.

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    Biological Activity

    DLK-LZK inhibitor 64 (example 64) is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK) inhibitor with IC50 of 2 nM and 10 nM, respectively.

    Physicochemical Properties

    M.Wt 451.494
    Formula C22H28F3N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1-(3-morpholinobicyclo[1.1.1]pentan-1-yl)-1H-imidazol-2-yl)-2-methylpropan-1-ol

    References

    1. U.S. Patent 20,180,186,781 A1, Exmaple 64.

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