Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DMA-135
Catalog No.: PC-72585Not For Human Use, Lab Use Only.
DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.
DMA-135 changes the local and global structure of the EV71 SLII IRES domain.
DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.
| M.Wt | 359.818 | |
| Formula | C16H18ClN7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
