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DMA-135 freebase

Chemical Structure : DMA-135 freebase

CAS No.: 2237925-61-8

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DMA-135 freebase (DMA135)

Catalog No.: PC-72586Not For Human Use, Lab Use Only.

DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
    DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.
    DMA-135 changes the local and global structure of the EV71 SLII IRES domain.
    DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.

    Physicochemical Properties

    M.Wt 323.360
    Formula C16H17N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-amino-N-carbamimidoyl-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide

    References

    1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.

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