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Chemical Structure : DMA-135 freebase
Catalog No.: PC-72586Not For Human Use, Lab Use Only.
DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
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DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.
DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.
DMA-135 changes the local and global structure of the EV71 SLII IRES domain.
DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.
| M.Wt | 323.360 | |
| Formula | C16H17N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.
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