DMAT is a potent, selective and cell permeable inhibitor of Casein Kinase 2 (CK2) with Ki of 40 nM, does not inhibit CK1 up to 200 uM.
DMAT inhibits caspase-mediated killing of human breast cancer cells with acquired resistance to antiestrogens.
DMAT reduces HCC growth by interference with NFκB- and Wnt-signaling.
DMAT induces reactive oxygen species and DNA double strand breaks.
