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Chemical Structure : DMP543
CAS No.: 160588-45-4
Catalog No.: PC-60687Not For Human Use, Lab Use Only.
DMP543 (XR-543) is a potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
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|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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DMP543 (XR-543) is a potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
DMP543 maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.
| M.Wt | 412.44 | |
| Formula | C26H18F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone |
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1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
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