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DMX-5804

Chemical Structure : DMX-5804

CAS No.: 2306178-56-1

DMX-5804 (DMX5804;DMX 5804)

Catalog No.: PC-36139Not For Human Use, Lab Use Only.

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM.

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Biological Activity

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM; displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR; rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O2; reduces infarct size and ischemia-reperfusion injury in mice in mice.

Physicochemical Properties

M.Wt 361.401
Formula C21H19N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

References

1. Fiedler LR, et al. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.

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