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DMXAA

Chemical Structure : DMXAA

CAS No.: 117570-53-3

DMXAA (ASA-404, Vadimezan)

Catalog No.: PC-42754Not For Human Use, Lab Use Only.

DMXAA (ASA-404, Vadimezan) is a vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM, also is a partial STING agonist, competes for human STING activation and STING dependent innate immune pathways.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DMXAA (ASA-404, Vadimezan) is a vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM, also is a partial STING agonist, competes for human STING activation and STING dependent innate immune pathways.

Physicochemical Properties

M.Wt 282.2906
Formula C17H14O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.5 mg/mL

Chemical Name/SMILES

9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo-

References

1. Phillips RM. Biochem Pharmacol. 1999 Jul 15;58(2):303-10.

2. Prantner D, et al. J Biol Chem. 2012 Nov 16;287(47):39776-88.

3. Shirey KA, et al. J Leukoc Biol. 2011 Mar;89(3):351-7.

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