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DNMDP

Chemical Structure : DNMDP

CAS No.: 328104-79-6

DNMDP (PDE3A inhibitor)

Catalog No.: PC-62220Not For Human Use, Lab Use Only.

DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression.

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Biological Activity

DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression.
The sensitivity of human cancer cell lines to DNMDP is correlated with PDE3A expression levels.
The aryl hydrocarbon receptor–interacting protein (AIP), a co-chaperone protein, is required for response to DNMDP.
AIP is also required for PDE3A-SLFN12 complex formation.

Physicochemical Properties

M.Wt 304.35
Formula C15H20N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[4-(diethylamino)-3-nitrophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

References

1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8.

2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043.

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