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Chemical Structure : DNMT/HDACi 15a
Catalog No.: PC-21991Not For Human Use, Lab Use Only.
DNMT/HDACi 15a is a potent, dual DNMT and HDAC inhibitor with IC50 of 57, 17 nM for HDAC1, HDAC6 respectively.
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DNMT/HDACi 15a is a potent, dual DNMT and HDAC inhibitor with IC50 of 57, 17 nM for HDAC1, HDAC6 respectively.
DNMT/HDACi 15a exhibits greater potency in inhibiting DNMT1 activity than DNMT3A and DNMT3B.
DNMT/HDACi 15a regulates the activities of DNMT1 and HDAC1 in breast cancer, decreases global DNA demethylation, induces downregulation of DNMT1 protein expression and upregulation of H3 acetylation in MDA-MB-453 and BT-474 cells.
DNMT/HDACi 15a exerts antitumour effects in vitro and in vivo, promote apoptosis and induce cell cycle arrest.
| M.Wt | 379.24 | |
| Formula | C18H16Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenjun Huang, et al. Cell Death Discov. 2024 Mar 15;10(1):143.
2. Yuan Z, et al. Eur J Med Chem 2017;134:281–92.
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