Chemical Structure : DNPH1 inhibitor 38
CAS No.:
DNPH1 inhibitor 38
Catalog No.: PC-25695Not For Human Use, Lab Use Only.
DNPH1 inhibitor 38 is a potent, non-nucleoside inhibitor of 2′-Deoxynucleoside 5′-monophosphate glycosidase (DNPH1, RCL) with binding pIC50 of 9.3, inhibits the hydrolysis of hmdUMP catalyzed by DNPH1 with pIC50 of 9.3.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DNPH1 inhibitor 38 is a potent, non-nucleoside inhibitor of 2′-Deoxynucleoside 5′-monophosphate glycosidase (DNPH1, RCL) with binding pIC50 of 9.3, inhibits the hydrolysis of hmdUMP catalyzed by DNPH1 with pIC50 of 9.3.
DNPH1 inhibitor 38 shows DNPH1 target engagement in the sub 100 nM range (pIC50=7.2).
DNPH1 inhibitor 38 (1 uM) increased DNA-bound hmdU in SUM149PT cells, selectively increases hmdU sensitivity in BRCA1m SUM149PT cells by 5-fold (IC50=0.6 uM), versus wild-type SUM149PT cell lines (IC50=2.7 uM).
Physicochemical Properties
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M.Wt
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603.58
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Formula
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C31H25F4N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2'-Fluoro-6-((6-methyl-4-((1-(pyrimidin-5-yl)pyrrolidin-3-yl)amino)quinazolin-2-yl)amino)-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic Acid
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References
1. Barlaam B, et al. J Med Chem. 2025 Nov 5. doi: 10.1021/acs.jmedchem.5c02356.
2. Rzechorzek NJ, et al. Nat Commun. 2023 Oct 26;14(1):6809.
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