DNS-0056 | PDE1B inhibitor | Probechem Biochemicals

Chemical Structure : DNS-0056

DNS-0056 (DNS0056)

Catalog No.: PC-26397Not For Human Use, Lab Use Only.

DNS-0056 is a potent, selective, orally bioavailable and brain-penetrating PDE1B inhibitor with IC50 of 26 nM, 40-fold selective over PDE10A.

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Biological Activity

DNS-0056 is a potent, selective, orally bioavailable and brain-penetrating PDE1B inhibitor with IC50 of 26 nM, 40-fold selective over PDE10A.
DNS-0056 exhibits good selectivity with regard to other PDE families.
DNS-0056 shows potent memory-enhancing effects in a rat model of object recognition memory.

Physicochemical Properties

M.Wt	483.56
Formula	C24H26FN5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one

References

1. Brian Dyck, et al. J Med Chem. 2017 Apr 27;60(8):3472-3483.

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DNS-0056 (DNS0056)

Biological Activity

Physicochemical Properties

References

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