DNS-pE2

Chemical Structure : DNS-pE2

Catalog No.: PC-62582Not For Human Use, Lab Use Only.

DNS-pE2 is the first small molecule that can selectively label endogenous 3-phosphoglycerate dehydrogenase (PHGDH) from various mammalian cells.

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Biological Activity

DNS-pE2 is the first small molecule that can selectively label endogenous 3-phosphoglycerate dehydrogenase (PHGDH) from various mammalian cells.
DNS-pE2 is highly fluorescent only upon irreversible covalent modification of PHGDH with an inhibitory property (in vitro Ki=7.4 uM).

Physicochemical Properties

M.Wt	285.361
Formula	C16H15NO2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-N-(prop-2-yn-1-yl)-6-(vinylsulfonyl)naphthalen-2-amine

References

1. Pan S, et al. Angew Chem Int Ed Engl. 2018 Jan 8;57(2):579-583.

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DNS-pE2

Biological Activity

Physicochemical Properties

References

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