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DPA-714

Chemical Structure : DPA-714

CAS No.: 958233-07-3

DPA-714 (DPA714)

Catalog No.: PC-62197Not For Human Use, Lab Use Only.

DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.
DPA-714 decreases microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration.
[18F]DPA-714 is a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET).

Physicochemical Properties

M.Wt 398.47
Formula C22H27FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide

References

1. James ML, et al. J Nucl Med. 2008 May;49(5):814-22.

2. Leaver KR, et al. ACS Chem Neurosci. 2012 Feb 15;3(2):114-9.

3. Reynolds A, et al. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5799-802.

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