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Chemical Structure : DPA-714
CAS No.: 958233-07-3
Catalog No.: PC-62197Not For Human Use, Lab Use Only.
DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DPA-714 is a potent, selective ligand for the translocator protein (TSPO) with Ki of 7.0 nM.
DPA-714 decreases microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration.
[18F]DPA-714 is a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET).
| M.Wt | 398.47 | |
| Formula | C22H27FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N,N-diethyl-2-[2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide |
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1. James ML, et al. J Nucl Med. 2008 May;49(5):814-22.
2. Leaver KR, et al. ACS Chem Neurosci. 2012 Feb 15;3(2):114-9.
3. Reynolds A, et al. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5799-802.
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