DPH is a cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
DPH binds to the myristoyl binding site, also stimulates in vitro c-Abl phosphorylation.
DPH induces both pY245 (pEC50=5.6) and pY412 c-Abl phosphorylation.
DPH dose dependently induces Crk-L pY207 in KG-1 cells.
DPH is the first small-molecule tool compound for c-Abl activation.
