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DQP-1105

Chemical Structure : DQP-1105

CAS No.: 380560-89-4

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DQP-1105 (DQP1105)

Catalog No.: PC-21029Not For Human Use, Lab Use Only.

DQP-1105 is a selective GluN2C- and GluN2D-containing NMDARs antagonist with IC50 of 7.0 and 2.7 uM respectively, >50-fold selectivity over GluN2A- or GluN2B-containing receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DQP-1105 is a selective GluN2C- and GluN2D-containing NMDARs antagonist with IC50 of 7.0 and 2.7 uM respectively, >50-fold selectivity over GluN2A- or GluN2B-containing receptors.
DQP-1105 also shows > 50-fold selectivity for recombinant GluA1-, or GluK2-containing receptors.
DQP-1105 inhibited single-channel currents in excised outside-out patches without significantly changing mean open time or single-channel conductance.

Physicochemical Properties

M.Wt 558.43
Formula C29H24BrN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)CCC(N1N=C(C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(C)=C4)CC1C5=CC=C(Br)C=C5)=O

References

1. Acker TM, et al. Mol Pharmacol. 2011 Nov;80(5):782-95.

2. N Lozovaya, et al. Nat Commun. 2014 Aug 1;5:4563.

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