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Chemical Structure : DQP-1105
Catalog No.: PC-21029Not For Human Use, Lab Use Only.
DQP-1105 is a selective GluN2C- and GluN2D-containing NMDARs antagonist with IC50 of 7.0 and 2.7 uM respectively, >50-fold selectivity over GluN2A- or GluN2B-containing receptors.
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DQP-1105 is a selective GluN2C- and GluN2D-containing NMDARs antagonist with IC50 of 7.0 and 2.7 uM respectively, >50-fold selectivity over GluN2A- or GluN2B-containing receptors.
DQP-1105 also shows > 50-fold selectivity for recombinant GluA1-, or GluK2-containing receptors.
DQP-1105 inhibited single-channel currents in excised outside-out patches without significantly changing mean open time or single-channel conductance.
| M.Wt | 558.43 | |
| Formula | C29H24BrN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Acker TM, et al. Mol Pharmacol. 2011 Nov;80(5):782-95.
2. N Lozovaya, et al. Nat Commun. 2014 Aug 1;5:4563.
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