DQP-997-74

Chemical Structure : DQP-997-74

Catalog No.: PC-21031Not For Human Use, Lab Use Only.

DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors.

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Biological Activity

Physicochemical Properties

M.Wt	570.37
Formula	C28H19Cl2F2N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ClC1=CC=C(C(C2=CC=CC=C2N3)=C(C4=NN(C(C(F)(F)CC(O)=O)=O)[C@H](C5=CC=C(Cl)C=C5)C4)C3=O)C=C1

References

1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.

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DQP-997-74

Biological Activity

Physicochemical Properties

References

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