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DQP-997-74

Chemical Structure : DQP-997-74

CAS No.: 2377187-09-0

DQP-997-74

Catalog No.: PC-21031Not For Human Use, Lab Use Only.

DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors.

Physicochemical Properties

M.Wt 570.37
Formula C28H19Cl2F2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ClC1=CC=C(C(C2=CC=CC=C2N3)=C(C4=NN(C(C(F)(F)CC(O)=O)=O)[C@H](C5=CC=C(Cl)C=C5)C4)C3=O)C=C1

References

1. Michael P. D'Erasmo, et al. ACS Chemical Neuroscience. August 11, 2023.

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