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DRAinh-A250

Chemical Structure : DRAinh-A250

CAS No.: 858747-13-4

DRAinh-A250 (SLC26A3 inhibitor)

Catalog No.: PC-35541Not For Human Use, Lab Use Only.

DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM.

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Biological Activity

DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM.
DRAinh-A250 does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels.
DRAinh-A250 blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum.
DRAinh-A250 reduces signs of constipation in loperamide-treated mice after oral treatment.

Physicochemical Properties

M.Wt 417.255
Formula C20H17BrO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(7-((3-bromobenzyl)oxy)-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid

References

1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370.

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