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Chemical Structure : DRAinh-A250
Catalog No.: PC-35541Not For Human Use, Lab Use Only.
DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM.
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DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM.
DRAinh-A250 does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels.
DRAinh-A250 blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum.
DRAinh-A250 reduces signs of constipation in loperamide-treated mice after oral treatment.
| M.Wt | 417.255 | |
| Formula | C20H17BrO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370.
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