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Chemical Structure : DRAinh-A270
Catalog No.: PC-38752Not For Human Use, Lab Use Only.
DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM.
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DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM.
DRAinh-A270 effectively inhibits oxalate absorption by 70% in colonic closed loops in mice.
DRAinh-A270 is effective in reducing intestinal oxalate absorption and preventing renal calcium oxalate deposition and injury in animal models of hyperoxaluria.
| M.Wt | 352.386 | |
| Formula | C21H20O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cil O, et al. JCI Insight. 2021 Jun 8;6(11):e147699.
2. Lee S, et al. J Med Chem. 2019;62(17):8330–8337.
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