Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DRP1i27
Catalog No.: PC-49583Not For Human Use, Lab Use Only.
DRP1i27 is a novel inhibitor of human Drp1 (mitochondrial dynamin-related protein 1), directly binds to and inhibits GTPase activity of human Drp1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DRP1i27 is a novel inhibitor of human Drp1 (mitochondrial dynamin-related protein 1), directly binds to and inhibits GTPase activity of human Drp1.
DRP1i27 induced both significant reduction in cell death induced by hydrogen peroxide treatment and a significant increase in the percentage of cells with elongated mitochondria.
DRP1i27 shows dose-response binding to human Drp1 isoform 3 with a KD of 286 (SPR) and KD of 190.9 uM (MST).
DRP1i27 5-50 µM showed a trend of inhibition of the conversion of GTP to GDP in the GTPase activity assay.
DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia–reperfusion injury.
| M.Wt | 366.469 | |
| Formula | C20H26N6O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Rosdah AA, et al. Sci Rep. 2022 Dec 13;12(1):21531.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
