Chemical Structure : DS-1039
CAS No.:
2231431-96-0
DS-1039
(DS1039)
Catalog No.: PC-25715Not For Human Use, Lab Use Only.
DS-1039 is a potent, selective GPR39 agonist, demonstrates excellent induction of intracellular Ca2+ concentration with EC50 of 0.01 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DS-1039 is a potent, selective GPR39 agonist, demonstrates excellent induction of intracellular Ca2+ concentration with EC50 of 0.01 uM.
DS-1039 shows no significant response with 168 other GPCRs and 87 molecular targets.
DS-1039 exhibitsexcellent induction of chloride secretion (EC50 = 0.051 μM) in hBE cells.
DS-1039 induces chloride channel opening in short circuit currents in 3D-cultured primary human bronchial epithelial cells.
DS-1039 induces calcium mobilization (EC50 = 1.0 μM) and chloride secretion (EC50 = 0.18 μM) in mouse bronchial epithelial cells, induces hyperpolarization in mouse NPD.
Physicochemical Properties
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M.Wt
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292.72
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Formula
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C14H13ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(2-chlorobenzyl)-4-methoxy-6-methylpyrimidine-2-carboxylic acid
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References
1. Muneoka S, et al. Eur J Pharmacol. 2025 Nov 15;1007:178257.
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