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Chemical Structure : DS-1558
Catalog No.: PC-61079Not For Human Use, Lab Use Only.
DS-1558 (DS1558) is a potent, selective, orally available GPR40 agonist with EC50 of 3.7 nM.
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DS-1558 (DS1558) is a potent, selective, orally available GPR40 agonist with EC50 of 3.7 nM.
DS-1558 (DS1558) shows no PPARγ agonistic activity up to 100 uM, and exhibits >100-fold selectivity over 68 other diverse receptors, ion channels and transporters.
DS-1558 (DS1558) has potent glucose lowering effects during an oral glucose tolerance test in ZDF rats.
| M.Wt | 394.39 | |
| Formula | C21H21F3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nakashima R, et al. Eur J Pharmacol. 2014 Aug 15;737:194-201.
2. Takano R, et al. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70.
3. Takano R, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5546-65.
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